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DEPARTMENT OF NEUROSURGERY

 

INTRODUCTION

 

Our department covers the entire spectrum of neurosurgical interventions. We treat patients with severe skull, brain and spinal injuries, degenerative spinal disorders, brain tumours, spinal tumours, degenerative spinal deformities, disorders in cerebrospinal fluid circulation and functional neurosurgery. We have extensive experience in neurointerventional treatments of hemorrhagic brain pathologies, the endovascular and open surgical interventions in vascular disorders of the brain and spinal cord. Within neuro-oncology, our clinic contributes to the multidisciplinary care of brain and spine tumours.

The annual number of open surgeries at the department is close to 2,000. The number of endovascular interventions, including the mechanical thrombectomies, exceeds 500 every year. Our department has 4 surgical sites. This entails a hybrid and an endovascular operating theatre, 3 specialist outpatient sites, 45 general beds and 11 neurointensive beds. We have a 25-bed rehabilitation unit, which helps patients to recover from severe craniocerebral injuries (neurotrauma, hemorrhagic and ischemic stroke). 

Our particular area of preference is neurointensive care. These include intervention, open surgery, neuromonitoring, neurointensive care, neurotraumatology, multimodal neuromonitoring, invasive brain pressure and autoregulation, brain temperature and oxygenation measurement, experimental implant trials in spinal surgery and resolution of cerebrovascular disorders. 

A multidisciplinary skull base surgery team collaborate with the Endochronology Unit of the Department of Internal Medicine 1, the Department of Ophthalmology and the Endoscopy Unit of the Department of ENT, Head and Neck Surgery. 

Our Head and Neck Surgery Unit works with the staff of the Department of Onco-Dermatology and the Department of ENT, Head and Neck Surgery. Our department treats patients from three counties (Baranya, Somogy and Tolna) of Hungary. However, it also takes patients on regional level from other counties (Zala, Bács-Kiskun, Veszprém and Vas) in the fields of functional neurosurgery, neuro-oncology, vascular pathologies and neurotraumatology. 

 

Number of clinical trial investigators with a Good Clinical Practice (GCP) certificate : 2
Number of clinical trial doctors with Good Clinical Practice (GCP) certificate: 8
Number of specialist doctors with Clinical Pharmacology certificate: 0
 

 

EQUIPMENTS CLINICAL TRIALS

 

  • Rrefrigerator - 80 °C
  • Transcranial Doppler ultrasound device
  • Blood gas analyzer
  • Centrifuge
  • Continuous Non-invasive Arterial Pressure (CNAP) measuring device


 

 

REFERENCE CLINICAL TRIALS

  

 

Protocol Identifier

Name of Study

Principal Investigator

1

NCT02210221

Collaborative European Neuro Trauma Effectiveness Research in TBI (CENTER-TBI)

Prof. Dr. András Büki

2

ATO-02

Biomarker Assessment For Neurotrauma Diagnosis and Improved Triage System (BANDITS)

Prof. Dr. András Büki

3

MRC

G0501444/NUTH 

3545

Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II)

Prof. Dr. András Büki

4

BHR-100-301

A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study to Investigate the Efficacy and Safety of Progesterone in Patients With Severe Traumatic Brain Injury (SyNAPSe)

Prof. Dr. András Büki

5

ATO-04

Biomarkers of Mild and Moderate Traumatic Brain Injury

Prof. Dr. András Büki

6

ATO-06

A Prospective Clinical Evaluation of Biomarkers of Traumatic Brain Injury (ALERT-TBI)

Prof. Dr. András Büki

7

ICH02 NCT01827046

Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III (MISTIE III) 

Prof. Dr. András Büki

8

ATO-12

A Prospective Evaluation of UCH-L1 and GFAP Biomarker Kinetics After Mild Brain Injury Trauma (VIGILANT)

Prof. Dr. András Büki

9

GDX-44-004

P03277 Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging

(MRI)

Prof. Dr. András Büki

 

 

OUR PUBLICATIONS

 

Synnot, A, RL Gruen, D Menon, EW Steyerberg, A Buki, W Peul, JH Elliott, and A Maas. 2019. “A New Approach to Evidence Synthesis in Traumatic Brain Injury.” JOURNAL OF NEUROTRAUMA. doi:10.1089/neu.2015.4124.

 

Maegele, M, H Schochl, T Menovsky, H Marechal, N Marklund, A Buki, and S Stanworth. 2017. “Coagulopathy and Haemorrhagic Progression in Traumatic Brain Injury: Advances in Mechanisms, Diagnosis, and Management.” LANCET NEUROLOGY 16 (8): 630–647. doi:10.1016/S1474-4422(17)30197-7.

 

Welch RD, Ayaz SI, Lewis LM, Unden J, Chen JY, Mika VH, Saville B, Tyndall JA, Nash M, Buki A, Barzo P, Hack D, Tortella FC, Schmid K, Hayes RL, Vossough A, Sweriduk ST, Bazarian JJ. Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury. J Neurotrauma. 2016 Jan 15;33(2):203-14. doi: 10.1089/neu.2015.4149. Epub 2015 Dec 18

 

 

 

PRINCIPAL INVESTIGATORS

 

Prof. Dr. András Büki 

SCIENTIFIC DEGREEPhD, DSc
POSITIONUniversity Professor 
QUALIFICATIONSneurosurgery, clinical oncology
SCIENTIFIC INTERESTtraumatic brain injury, diffuse axonal damage
REFERENCE CLINICAL TRIALS

ATO-02: Biomarker Assessment For Neurotrauma Diagnosis and Improved Triage System (BANDITS). 
Number of patients: 103

ATO-04: Biomarkers of Mild and Moderate Traumatic Brain Injury Observational study.
Number of patiens: 48

ATO-06: A Prospective Clinical Evaluation of Biomarkers of Traumatic Brain Injury (ALERT-TBI) Observational study.
Number of patiens: 80

NCT02210221: Collaborative European Neuro Trauma Effectiveness Research in TBI (CENTER-TBI) Observational study. 
Number of patiens: 43


GDX-44-004 P03277: Dose Finding Study in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) PhaseIIb Clinical Study. 
Number of patiens: 59 

AVAILABLE FOR PERFORMING CLINICAL TRIALSPhase 1-4

 

 

 

STUDY TEAM

 

We carry out clinical trials by using the Coordination Centre for Clinical Trials (KVKK).

 

 

 

 

 

Created: 20.11.2019.
Last modified: 20.11.2019.